Transcriptional changes in the prefrontal cortex are associated with cognitive impairment in an experimental mouse model of multiple sclerosis
Maria Concetta Geloso, Annalisa Adinolfi, Luca Zupo, Marika Guerra, Marco Pieraccioli, Francesco Ria, Eleonora Cesari, Valentina Corvino, Gabriele Di Sante, Claudio Sette · FENS Forum 2024
Gray matter damage underlies progressive cognitive impairment (CI) in multiple sclerosis (MS). To identify transcriptome changes associated with CI, we analyzed the prefrontal cortex (PFC), a brain region relevant for cognition, at the acute phase of experimental autoimmune encephalomyelitis (EAE), a well-established mouse model of MS. High-throughput RNA-sequencing coupled with bioinformatics analyses highlighted the significant up-regulation of cytokine-mediated and inflammatory pathways in the PFC of EAE-mice. Heat-map representation of the top 100 regulated genes indicated the presence of
ePoster · Neuroscience