Dysregulation in microglia-related immune responses in cognitive impairment associated with Parkinson’s disease
Maria Francesca Palmas, Michela Etzi, Maria Francesca Manchinu, Francesca Isabella Diana, Jacopo Marongiu, Mauro Pala, Claudia Sagheddu, Michele Santoni, Giuliana Fusco, Alfonso De Simone, Marco Pistis, Augusta Pisanu, Anna Rosa Carta · FENS Forum 2024
Mild cognitive impairment (MCI) is a common trait of Parkinson's disease (PD), often associated with early motor deficits, eventually evolving to PD with dementia in later disease stages. The neuropathological substrate of MCI is poorly understood, thus few studies pointed at immune dysfunctions as a contributing factor. We tested this hypothesis in an α-synuclein (αSyn)-based model of PD obtained by the intranigral infusion of human α-synuclein oligomers (H-SynOs). Three months after infusion rats developed mild cognitive deficits sustained by an altered electrophysiological activity in the a
ePoster · Neuroscience