Spatial and functional profiles distinguish target sets of Parkinson’s disease and schizophrenia drugs with different clinical outcomes
Kalyani Karunakaran, Sanjeev Jain, Darius Widera, Graeme Cottrell · FENS Forum 2024
Several studies have examined the genetic factors shared between Parkinson’s disease (PD) and schizophrenia (SZ), but the biological themes underlying their clinical relationship remain less explored. We employed systematic transcriptomic and network analyses (Figure 1) to examine the genes targeted by two sets of antipsychotic drugs (APDs), first-generation APDs inducing Parkinsonism and second-generation APDs typically effective against psychotic symptoms in PD. We also examined two sets of PD drugs, i.e., those that were contraindicated in SZ, or not. We found that, although global brain ex
ePoster · Neuroscience