Behavior and cellular alterations in a pre-clinical model of Parkinson’s disease with abrogated adult hippocampal cytogenesis
Bruna Araújo, Rita Caridade-Silva, Ana Catarina Vilaça-Ferreira, Joana Martins-Macedo, Catarina Teixeira, Carla Soares-Guedes, Per Svenningsson, Luísa Pinto, Fabio Gabriel Teixeira · FENS Forum 2024
Deficits in adult hippocampal neurogenesis (AHN) is a common feature in depression and Parkinson’s Disease (PD). Actually, depressive disturbances occur in 40–50% of patients with PD, influencing many clinical aspects of the disease. Indeed, PD patients and mice models exhibited fewer proliferating cells in the subventricular zone and dentate gyrus (DG). Since both regions comprise dopaminergic innervation and inputs from the nigrostriatal areas, it is plausible that dopaminergic system may exert some control over or under cytogenic brain regions.To investigate this, we used a transgenic rat (
ePoster · Neuroscience