Decoding the developmental vulnerability to psychiatric disorders: Investigating the sexual dimorphism and role of perineuronal nets in habenulo-interpeduncular-system-mediated susceptibility to anxiety
Niels Fjerdingstad, Malalaniaina Rakotobe, Adrien Chopin, Thomas Lamonerie, Fabien D'AUTREAUX · FENS Forum 2024
Psychiatric disorders are among the most common causes of years lived with disability. Yet, we lack a solid understanding of their onset and course, and current treatments are unsatisfactory. To offset this predicament, the study of critical periods (CPs) of development sets the focus on the roots of psychiatric disorders, when susceptibility to these illnesses is being installed but not yet set off, in order to better understand the underlying mechanisms.Recently, we identified in mice the CP of a brain circuit, the Habenulo-Interpeduncular-OTX2-Positive-System (HIPOPS), regarding stress resp
ePoster · Neuroscience