Reduced pain thresholds in two Parkinson's disease mice models
Carlos Salas Prieto, Esther Berrocoso, Alexander Binshtok, Joshua Golberg, Rosario Moratalla · FENS Forum 2024
Pain is considered one of the most frequent non-motor symptoms of Parkinson’s disease (PD) and it usually manifests before the motor symptoms. Although not considered one of the cardinal symptoms of PD, pain affects up to 80% of PD patients and half of them report multiple types of pain. The cause of this pain is still unknown, but it may be due to dysfunction of key nuclei in the processing of nociceptive information.In order to determine the possible causes of this prodromal symptom, we use different parkinsonian models, such as the hα- syn1-120 model, which presents a differential expressio
ePoster · Neuroscience