Pre- and post-treatment with apigenin attenuates status epilepticus-induced neuronal death by reducing oxidative stress and inflammation in the mouse brain
Latifa Bulbul, S.M. Kamruzzaman, Rubel Hossain · FENS Forum 2024
Status epilepticus (SE) is a prolonged, recurrent seizure leading to neuronal damage. Given the limitations of existing treatment modalities, exploring new alternatives is imperative. Emerging research suggests that inflammatory processes are implicated in epileptogenesis. Apigenin (AP), an antioxidant and anti-inflammatory flavonoid, demonstrates neuroprotective effects in brain disorders. Nevertheless, its significance in status epilepticus remains unstudied. Therefore, we investigated whether AP alleviates pilocarpine (PLO)-induced SE neuropathology. We propose that AP may reduce SE by atte
ePoster · Neuroscience