Human microglia cells in Alzheimer disease-derived brain organoids: Can it be a good model?
Eva Cano, Andrés Fernández, Patricia Velasco, Belén Moreno-Jiménez · FENS Forum 2024
Neuroinflammation, which refers to the inflammatory response occurring in various Central Nervous System (CNS) disorders, is a relatively recent concept. It involves two main types of cells: astrocytes, which play a significant role in the process, and brain myeloid cells (BMC), crucial players in neuroinflammation.Studies examining the entire genome (GWAS) have pinpointed over 30 genetic loci associated with Alzheimer's disease (AD), many of which relate to innate immunity and the function of microglia, notably the apolipoprotein E (APOE) gene. APOE4 is particularly significant, being the str
ePoster · Neuroscience