Topic: APP proteolytic cleavage

Synapse loss is a key feature of cognitive decline in Alzheimer’s disease (AD). Emerging evidence points toward the involvement of glial cells, alongside neurons, in disease progression. Understanding how glia remodel synaptic connections is crucial for understanding the onset of AD. Additionally, in the context of AD-specific risk genes, how this intricate balance is disrupted will aid in deciphering early disease mechanisms. In this study, primary glia cells were co-cultured in 3D with primary neurons pre-treated with pharmacological modulators targeting amyloid precursor protein (APP) proce