The brain-gut axis in Alzheimer’s disease: Insights into a new clearance mechanism of amyloid beta peptide and tau protein
Maxime Seignobos, Sylvie Boisseau, Frédérique Vossier, Alain Buisson, Muriel Jacquier-Sarlin · FENS Forum 2024
Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by cerebral accumulation of extracellular plaques of aggregated amyloid-β (Aβ) peptide, neurofibrillary tangles composed of truncated and hyperphosphorylated Tau protein, both leading to synaptic loss, and neuronal death. To ensure cerebral homeostasis, several elimination mechanisms exist for these toxic proteins. Recently, a complex mechanism based on exchanges between different extracellular space has been identified in the brain: the glymphatic system. Our aim is to study how the brain-gut axis participates
ePoster · Neuroscience