Protein levels and post-translational modifications of inhibitory synapse proteins in the mammalian brain are regulated by the plant-derived artemisinins
Eva Kiss, Stefan Kins, Gabriela Patrichi, Kinga Hajnal Venczel Szakács, Karin Gorgas, Joachim Kirsch, Jochen Kuhse · FENS Forum 2024
Disrupted balance between excitatory and inhibitory neuronal activity is considered a main driver of AD pathogenesis contributing to cognitive deficits. We studied the protein expression of GABAA- and glycine receptor subunits as well as the protein level and phosphorylation of the inhibitory receptor anchoring protein gephyrin in a mouse model of AD and how treatment with artemisinins modulates these features. In hippocampal subregions of 12-months-old double transgenic mice which co-express the Swedish mutated form of the human APP (APPswe) and at L166P mutated human presenilin 1 (PS1) genes
ePoster · Neuroscience