Activation of NOTCH pathway in brain endothelial cells ameliorates vascular abnormalities in Alzheimer's disease mouse models
Silvia Quiñones Cañete, Juan Luis López Ogáyar, María Isabel Álvarez Vergara, David Macías, Alicia Elena Rosales Nieves, Alberto Pascual · FENS Forum 2024
In previous studies, we identified low-perfused vascular abnormalities, termed “vascular scars”, surrounding A-beta plaques in Alzheimer's disease mouse models. We hypothesized that these vascular scars result from non-productive angiogenesis, a process in which total or partial reduction of the DLL4/NOTCH pathway leads to erratic angiogenesis and disassembly of vessels into non-conducting structures1. In this study, our objective was to investigate whether restoring the NOTCH pathway in brain endothelial cells could enhance vessel stability around A-beta plaques. To this aim, we injected the
ePoster · Neuroscience