Topic: appetite signaling

Despite an overall increase in caloric needs, regular physical activity has been associated with improved appetite signaling. The neurobiological mechanisms underlying this sensitization remain unclear. We employed a voluntary wheel running protocol to investigate how physical activity affects gut-brain communication of vagal sensory neurons for the control of feeding behavior in mice. We find that physically active mice exhibit a significant decrease in food intake in response to the delivery of nutrients directly into the stomach, as compared to sedentary controls. Further, sensitivity to ch