An altered regulation of Flotillin-1 in Alzheimer’s disease
Subash Chandra Malik, Yang Yu, Sophia Schedin-Weiss, Lars Tjernberg · FENS Forum 2024
Flotillins are highly conserved integral membrane proteins which play a role in several key biological processes including vesicular trafficking, endocytosis, and cytoskeletal organization. Some studies have reported that flotillin-positive extracellular vesicles can be used as biomarker for AD diagnosis in blood samples. Due to its constitutive expression, flotillins can be expressed by many cell types. Our aim was to characterize the expression and localization of Flot1 in neurons and deduce the potential role of Flotillin-1 (Flot1) in AD. We use super-resolution microscopy methods such as A
ePoster · Neuroscience