The parvalbumin-interneuron mediated modulation of a memory engram in the context of Alzheimer’s disease
Thije Willems, Harm Krugers, Helmut Kessels, Sylvie Lesuis · FENS Forum 2024
Neuronal network imbalance and synaptic dysfunction both critically contribute to cognitive decline in AD. Network imbalance is increasingly recognized as an early characteristic of AD, which might precede and drive clinical symptoms. Early alterations in parvalbumin (PV+) interneurons contribute to this network dysfunction in AD mouse models. However, to what extent this shapes how memories are stored within the brain and drives cognitive decline remains to be determined. Our objective is to investigate synaptic, local, and network imbalances in AD, as well as their mutual dependence.We used
ePoster · Neuroscience