Deciphering the role of locus coeruleus for hippocampus-dependent learning and its impairment in a mouse model of Alzheimer’s disease
Hanna Khomyak, Falko Fuhrmann, Martin Fuhrmann, Stefanie Poll · FENS Forum 2024
Locus Coeruleus (LC) is a neuromodulatory system that is heavily affected at an early stage of Alzheimer´s Disease (AD) progression. In human AD patients, the LC shows an extensive loss of neurons. Therefore, the goals of this project are to examine the influence of the LC on HPC-dependent mnemonic processes and on their impairment in AD. To achieve this, we explored, whether the structural and functional connectivity between the LC and the HPC is altered in an APPswe/PSEN1dE9 mouse model of AD. We found a significant reduction of LC to HPC projections identified by immunohistochemically stain
ePoster · Neuroscience