Molecular profiling of Arc neuronal ensembles supporting the encoding of drug-context associations
Marine Salery, Arthur Godino, Yu Qing Xu, John F Fullard, Romain Durand-de Cuttoli, Alexa R LaBanca, Leanne M Holt, Scott J Russo, Panos Roussos, Eric J Nestler · FENS Forum 2024
Learned associations between the rewarding effects of drugs and the context in which they are experienced are decisive for precipitated drug-seeking and relapse in addiction. Such associative memories are stored in sparse and highly discriminative populations of concomitantly activated neurons defining drug-recruited ensembles. In this study, we explore the dynamics of recruitment of these ensembles through the encoding, strengthening and expression of cocaine-context associative memories. Additionally, we characterize the intrinsic (phenotypical) or acquired (plastic) cellular properties that
ePoster · Neuroscience