The microglial modulation of a memory engram in the context of Alzheimer’s disease
Niek Renckens, Thije S. Willems, Paul J. Lucassen, Helmut W.H.G. Kessels, Harm J. Krugers, Sylvie L. Lesuis, Aniko Korosi · FENS Forum 2024
Alzheimer's Disease (AD), responsible for the majority of dementia cases, is a progressive neurodegenerative disorder marked by amyloid-β accumulation, tauopathy, neuroinflammation, and cognitive decline. Parallel to this cognitive decline, the number of memory-related neurons (engram cells) is reduced in the APPswe/PSEN1dE9 mouse model for slow-progressing AD, crossed with a genetically modified mouse line that allows us to visualize engram neurons (Arc::dVenus mice). We hypothesize that aberrant microglial modulation of engram cells might contribute to the AD-related changes in engram and co
ePoster · Neuroscience