ePoster · Neuroscience
H3K9me3 reduces neuron activation in the aged dentate gyrus
Citlali Suárez Rangel, Aleph Prieto · FENS Forum 2024
Recent evidence suggests that epigenetic mechanisms may contribute to memory deficits in aging. Specifically, in the hippocampus, the repressive epigenetic mark H3K9me3 (tri-methylated lysine 9 on histone H3) has been implicated in the silencing of genes essential for memory. Yet, the impact of the age-related increased H3K9me3 levels on neuronal function remains unclear. We hypothesized that H3K9me3 accumulation renders neurons refractory to stimulation. To assess the influence of H3K9me3 on neuronal activation, we reduced H3K9me3 levels by silencing the major methyltransferase responsible to