Investigation of the effects of high-calorie diet on synaptic neurotransmission in the ARCTH → PVH neural circuit by optogenetic and electrophysiological methods
Yavuz Yavuz, Huseyin Bugra Ozgun, Deniz Oyku Ozen, Habibe Goren, Bayram Yilmaz · FENS Forum 2024
Tyrosine hydroxylase (TH) expressing neurons in the arcuate nucleus of hypothalamus (ARC), has a central role in regulating appetite and metabolism. It has been shown that activity changes in these neurons are necessary and sufficient to acutely regulate feeding behavior. TH neurons send dense intrahypothalamic axonal projections and make synaptic connections to paraventricular nucleus (PVN), which have been shown to be the key downstream target region. Since the ARCTH→PVN synaptic connection plays a crucial role in feeding, possible changes in the strength of this connection are also likely t
ePoster · Neuroscience