Topic: area under the curve (AUC)

Methamphetamine (MA) is a psychostimulant with a high potential for abuse and neurotoxic effects, primarily affecting the brain's monoamine neurotransmitter systems. Recently, its overdose or concurrent use with alcohol (EtOH) has been associated with a notable increase in hospitalizations and mortality. In this study, we examined locomotor behavior, as well as metabolic and pharmacokinetic interactions, following the co-administration of low, medium, and high doses of MA (hydrochloride salt, 1, 4, and 10 mg/kg, intraperitoneal) and EtOH (2 g/kg, 30%, v/v, intraperitoneal) in rats. Locomotion