Genetic background determines synaptic phenotypes in ARID1B haploinsufficient mice
Hyosang Kim, Doyoun Kim, Yisul Cho, Kyungdeok Kim, Junyeop Roh, Yangsik Kim, Esther Yang, SeongSoon Kim, Sunjoo Ahn, Hyun Kim, Hyojin Kang, Yongchul Bae, Eunjoon Kim · FENS Forum 2024
In the first study, we showed that early chronic fluoxetine treatment restore autism-like behavioral abnormalities via excitatory synapse-related transcriptomic reprogramming in ASD-model mouse. We characterized that deletion of ARID1B caused ASD-like behavioral deficits through persistently decreased density of excitatory synapses starting juvenile stage. Pharmacological correction using early chronic fluoxetine treatment targeting first three weeks after birth successfully carried out long-lasing rescue effects on synaptic deficits and behavioral abnormalities. The other study, however, clai
ePoster · Neuroscience