Distinct brain states modulate visual cortical processing in mouse
Shailaja Akella, Peter Ledochowitsch, Joshua H. Siegle, Hannah Belski, Michael A. Buice, Severine Durand, Christof Koch, Shawn R. Olsen, Xiaoxuan Jia · COSYNE 2023
Variations in brain states and behavioral profiles clearly influence neuronal activity in the visual cortex[1,2]. However, the mechanisms behind these influences and their consequent effect on sensory encoding remain to be determined. Here, we address this issue by analyzing simultaneous recordings of spiking activity and local field potentials (LFPs) from visual and subcortical regions of (N = 25) awake mice viewing a naturalistic movie. Applying a hidden Markov model (HMM) to cortical LFPs, we consistently identified three stable states in each mouse: a high-frequency state (dominated by gam
Sun, Mar 12, 2023