Modelling synaptic tau and Aβ pathology in human organotypic brain slice cultures
Robert McGeachan, Soraya Meftah, Lewis Taylor, Jamie Rose, Imran Liquat, Sam Booker, Paul M Brennan, Tara Spires-Jones, Claire Durrant · FENS Forum 2024
Neurodegenerative diseases like Alzheimer’s disease and Progressive Supranuclear Palsy (PSP) exhibit synaptic loss. In these conditions, synaptic loss precedes neuronal degeneration, and the degree of synaptic loss correlates closely with the severity of clinical symptoms. Both Aβ, which accumulates in amyloid plaques in AD, and tau protein which accumulates intracellularly in tauopathies, accumulate within synaptic terminals. In model systems, the accumulation of Aβ and tau in synapses has been linked to synaptic dysfunction, synaptic loss, and the spread of pathology trans-synaptically. Howe
ePoster · Neuroscience