Unconventional intracellular signaling pathway underlying cholinergic muscarinic receptor-induced axonal action potential threshold plasticity in hippocampal neurons
Haojie Sun, Rafael Lujan, Mala Shah · FENS Forum 2024
Acetylcholine is a neurotransmitter and neuromodulator that critically modulates cognition. We have shown that acetylcholine activates axonal muscarinic receptors in hippocampal dentate gyrus granule neurons to persistently lower the action potential (AP) threshold and enhance neuronal excitability1. This was due to a sustained increase in T-type Ca2+ channel activity resulting in elevated basal Ca2+ levels which inhibited KV7 channels. The intracellular mechanism coupling axonal muscarinic receptors to T-type Ca2+ channels remains unknown. We investigated this by making electrophysiological r
ePoster · Neuroscience