Transient receptor potential ankyrin type 1 (TRPA1) channel, a new target for the antimalarial artemisinin
Ramona Madalina Babes, Deborah-Elena Huțanu, George Oprița, Dan Domocoș, Tudor Selescu, Alexandra Manolache, Teodora Stratulat, Susanne Sauer, Sorin Tunaru, Alexandru Babes · FENS Forum 2024
The molecular mechanism of the antimalarial artemisinin and its derivatives is not yet fully understood, although these compounds are successfully used against Plasmodium protists. Other biological effects (anti-cancer or antinociceptive effects) are also possible following administration of artemisinin. Considering that Transient Receptor Potential (TRP) ion channels are key signalling molecules in many cancer and pain pathways, the aim of this study was to test whether members of this family are among the molecular targets of artemisinin. The effect of artemisinin on wild type or mutant TRP
ePoster · Neuroscience