Self-assembly of the mammalian neocortex, from mouse to macaque
Gabriela Michel,Rodney Douglas,Andreas Hauri,Sabina Pfister,Marion Betizeau,Frederic Zubler,Colette Dehay,Henry Kennedy,Kevan Martin · COSYNE 2022
Sat, Mar 19, 2022
During mammalian neural development, mitotic cells sense local cues and morphogenic gradients to form complex and coherent processing systems, such as the cerebral cortex, that contains billions of neurons classified into different cell types. We use agent-based simulations of cellular growth and differentiation to explore and understand the regulatory principles governing cortical development in mouse and macaque. We use the java platform Cx3D, which provides methods for detailed simulations of genetic networks and also physical cellular processes in a 3-D space. First, we derive an artificia