Topic: Asc1

Glycinergic synapses between the medial nucleus of the trapezoid body (MNTB) and the lateral superior olive (LSO) are involved in sound source localization. These synapses can reliably transmit inhibitory signals, even during minutes of high-frequency activation. Glycine transporter 2 (GlyT2) is involved in glycine reuptake from the synaptic cleft into MNTB axon terminals. Loss of GlyT2 reduces the synaptic transmission but does not lead to a complete failure (Brill et al 2021). The resilience suggests the presence of another glycine source. Here we investigated the contribution of Asc1, a hig