Topic: ascending proprioceptive pathway

Adaptive motor control requires the integration of proprioceptive and other sensory signals. However, the principles, which govern the processing of proprioception, are poorly understood. Here, we employ a task-driven modeling approach to quantitatively test hypotheses about the functional role of proprioceptive neurons in cuneate nucleus, which is the projection target of ascending spindle neurons in the brain stem. We generated datasets of realistic proprioceptive, muscle spindle inputs for a large, diverse repertoire of movements (following Sandbrink et al., bioRxiv, 2020), and used them to