Analysis of differences in hippocampal adult neurogenesis induced by acute mild and severe seizures in young mice
Diana Laura López Ibarra, Verónica Gaytán Zerón, Teresa Montiel, Lourdes Massieu, Angélica Zepeda Rivera · FENS Forum 2024
Adult hippocampal neurogenesis (AHN) occurs in the subgranular zone (SGZ) of the dentate gyrus (DG) in mice and can be modulated by events such as hyperexcitability present in epilepsy. Evidence shows increased aberrant AHN in chronic severe epilepsy models; however, the impact of mild seizures remains to be explored. In this study, we administered intraperitoneally a low (5mg/kg) or a high dose (25 mg/kg) of kainic acid (KA) to Ascl1/Tom young mice (6-8 weeks) that allow us to target new neurons, to induce acute mild or acute severe seizures, respectively and evaluate differences in neurons b
ePoster · Neuroscience