Topic: Ascl4

Recent studies have shown that molecular programming by basic helix-loop-helix (bHLH) proteins can reactivate wiring in adult neurons. Meanwhile circuit analyses in these studies demonstrated functional circuit formation, the underlying molecular mechanisms remain elusive. Here, we used RNAseq, mass-spectrometry, and immunohistochemistry to investigate the transcriptomic and proteomic consequences of Id2 (a regulator of bHLH transcription factors) and Ascl4 (a bHLH transcription factor)-induced wiring in adult hippocampal granule cells, which lead to the formation of mainly feedback and feedfo