The impact of autism spectrum disorder-risk genes on human neural stem cell proliferation and survival
Francesca Barbieri, Gintarė Sendžikaitė, Martina Rispoli, Simon Haendeler, Denise Haslinger, Hagar Moussa, Arndt von Haeseler, Gaia Novarino · FENS Forum 2024
The development of autism spectrum disorder (ASD) is strongly influenced by genetic factors. To navigate the large number of genes associated with the disorder, recent efforts have been directed towards finding functional convergence among ASD-risk genes. Within the biological processes commonly affected in ASD, cell proliferation is of particular interest, given the occurrence of brain volume anomalies in a significant subset of the ASD population. Since neural stem cells are key players in the expansion of neural cell pools throughout development, we hypothesized that a group of ASD-risk gen
ePoster · Neuroscience