Role of CRF signalling in the lateral septum system in the regulation of social fear extinction
Atefeh Akbari, Rohit Menon, Inga Neumann · FENS Forum 2024
Social anxiety disorder (SAD) is caused by stressful social encounters. The Social Fear conditioning (SFC) paradigm is able to effectively simulate the symptoms of social phobia, such as a severe fear and avoidance of social situations. The extinction phase of the SFC paradigm mimics exposure therapy for SAD and facilitates the learning of the disassociation between the trauma and the social context. The lateral septum (LS), known to be involved in socio-emotional regulation, abundantly expresses corticotropin-releasing factor receptors (CRFR1/CRFR2) and several lines of evidence implicate the
ePoster · Neuroscience