Topic: astrocytes-neurons communication

The widespread use of herbicides, including glyphosate (Gly), is thought to represent a potentially underestimated risk to human health. The putative absence of the known direct target molecular pathway of Gly in mammalian cells has assured its safety and EFSA established the acceptable daily intake (ADI) dose for humans at 0,5 mg/kg body weight. However, very little is known about Gly neurotoxicity at this dosage, especially on intricate mechanism such as the communication between brain cells. Astrocytes contribute to neuron maturation, survival, and modulation of synaptic activity also throu