Consequences of chronic kidney disease on neurodegenerative processes in 5/6Nx rat models
Irene Cortijo, Françoise Trousse, Fabrice Raynaud, Pascaline Fontès, Jonas Laget, Seniha Pehlivan, Marie-Christine Lebart, Nathalie Gayrard, Angel Argilés, Anne Marcilhac · FENS Forum 2024
Recent findings reveal an increased risk of cognitive impairment in individuals with chronic kidney disease (CKD). To better understand the interactions between CKD and neurodegenerative diseases, twenty Sprague Dawley rats underwent either 5/6 Nephrectomy (Nx) or Sham operation through random allocation at two different time onsets: six or twelve weeks of age. Twenty-four weeks after surgery, renal function and histopathological parameters were evaluated. The 5/6Nx rats showed increased blood creatinine and urea levels as well as kidney inflammation at both time onsets. This renal damage appe