Evaluation of ultrastructural correlates for neuronal membrane remodeling during TTX-induced synaptic plasticity
Gudrun Brandes, Amelie Eichler, Hanna Hemeling, Maximilian Lenz · FENS Forum 2024
Synaptic plasticity is a fundamental process underlying learning and memory, modulating neuronal connectivity through complex mechanisms that include neuronal membrane remodeling. This study investigates the ultrastructural correlates of membrane homeostasis during tetrodotoxin (TTX)-induced synaptic plasticity in murine entorhino-hippocampal tissue cultures. Using transmission electron microscopy, we aimed to: (1) analyze presynaptic vesicles to evaluate presynaptic targets of TTX-induced plasticity, (2) evaluate multivesicular and lamellar bodies after activity deprivation in different neuro
ePoster · Neuroscience