Astrocytes phagocytic sexual dimorphism fosters major depressive disorder through MEGF10 dysfunction
Diego Julian Vesga Jimenez, Eugenia Vivi, Celia Román, Lea Seeholzer, Rachel Breton, Nathalie Rouach, Inga. D Neumann, Barbara Di Benedetto · FENS Forum 2024
Major Depressive Disorder (MDD) is a prevalent global cause of disability, affecting approximately 5% of adults, and has a higher incidence in females. Despite its significant impact, its diverse symptoms and causes lack clear identification, hindering effective treatments. Understanding the underlying mechanisms is crucial. Studies in various brain areas indicate an astrocyte pathology in MDD, revealing reduced numbers and altered morphology, gene, and protein expression. Astrocytes influence synapse remodeling, crucial for neuronal network maturation. Notably, their phagocytic ability, facil
ePoster · Neuroscience