Dynamical complexity in engineered biological neuronal networks with directional and modular connections
Nobuaki Monma, Hideaki Yamamoto, Hakuba Murota, Satoshi Moriya, Ayumi Hirano-Iwata, Shigeo Sato · FENS Forum 2024
Brain-on-a-chip, a method for reconstructing neuronal networks with brain-like properties in a cultured environment, has attracted attention for investigating the relationship between connection structure and activity patterns. As fundamental technologies for realizing such devices, bioengineering technologies to reconstruct modular structure and directional connection with living cells have been developed previously, they have not been integrated to realize modular networks with directionality. In this study, we developed a novel microfluidic device to reconstruct such network with cultured c
ePoster · Neuroscience