A new zebrafish transgenic line expressing human alpha-synuclein to study the biological basis of Parkinson’s disease
Silvia Zini, Alessia Muscò, Francesca Longhena, Gaia Faustini, Giuseppe Borsani, Daniela Zizioli, Arianna Bellucci · FENS Forum 2024
Compelling evidence supports that exploiting both patient-derived and animal models is pivotal to reach a better understanding of Parkinson’s disease (PD) (DOI:10.1002/mds.28387). However, working with in vivo models can be challenging as most of them only partially reproduce the pathology at advanced age.We recently developed a novel zebrafish transgenic (tg) line expressing human full-length alpha-synuclein (aSyn) with an N-terminal mCherry tag named Tg(elavl3:mCherry-hsa.SNCA) which exhibit a series of PD-like features already in the larval stage. At 5 days-post-fertilization (dpf), Tg(elav
ePoster · Neuroscience