Topic: ASYN-WT

Alpha-synuclein (ASYN) is a presynaptic neuronal protein related genetically and neuropathologically to Parkinson's disease (PD). However, the role of ASYN in the selective degeneration of specific neuronal populations such as the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc) remains elusive. Since previous strategies for viral overexpression of ASYN in animals are not cell-type specific, we generated novel adeno-associated viral vectors (AAV) to Cre-dependently express human wild-type ASYN (ASYN-WT) or ASYN with pathogenic A53T or A30P mutations. This strategy allo