Zebrafish infection model to study oral bacteria-driven neuroinflammation
Dawid Kozłowski, Magdalena Widziołek, Anna Mieszkowska, Magdalena Marcinkowska, Jan Potempa, Magdalena Chadzińska · FENS Forum 2024
Recently, neurodegenerative diseases are more often linked with oral bacteria-driven infections. However, it is not clear how central nervous system pathologies root from infections of the oral cavity. Porphyromonas gingivalis (Pg) is a key-stone pathogen in periodontitis, a chronic inflammatory disease of the gingival and teeth-supporting structures. Many studies suggest that differences in infection severity and systemic pathologies are linked with different Pg strains and produced virulence factors. In this study, we used a zebrafish (Danio rerio) infection model, widely used in biomedical
ePoster · Neuroscience