Noradrenergic agonists as new treatment opportunity against radiation-induced cognitive decline
Isabeau De Bie, Bo Peeters, Lisa Berden, Christian Vanhove, Tom Boterberg, Kevin Tabury, Irina Primac, Robrecht Raedt, Rafi Benotmane · FENS Forum 2024
Aims: Pediatric patients undergoing cranial irradiation are at risk of developing neurocognitive impairments. Mechanistically, radiation-induced injury to the hippocampi could play an important role in this debilitating condition, by inducing loss of neural stem/progenitor cells and neuroinflammation within this region. Noradrenergic (NA) agonists can potentially mitigate this radiation-induced cognitive decline by reducing cell death and inflammation. Therefore, we hypothesize that boosting NA through drugs will attenuate radiation-induced impairments in neurogenesis and decrease neuroinflamm
ePoster · Neuroscience