A loss of spiral ganglion neurons with an active ATOH1 enhancer alters hearing function
Kateryna Pysanenko, Mitra Tavakoli, Romana Bohuslavova, Josef Syka, Bernd Fritzsch, Gabriela Pavlinkova · FENS Forum 2024
Background: ATOH1 is recognized as a crucial transcription factor for hair cell differentiation. Although Atoh1 expression has been documented in a subset of developing spiral ganglion neurons, its specific role in neuronal development remains to be elucidated.Methods: We generated a novel conditional deletion model (Atoh1Cre-Isl1CKO) targeting Isl1 in the inner ear. Immunohistochemistry was used to examine morphological and cellular changes in the inner ear. Additionally, we assessed the hearing function of Atoh1Cre-Isl1CKO mutants compared to littermate control mice using auditory brainstem
ePoster · Neuroscience