Chronic ototoxicity induces downregulation of hair cell-specific genes in the vestibular sensory epithelium of rodents
Mireia Borrajo, Alberto Maroto, Erin A. Greguske, Aïda Palou, Marta Gut, Anna Esteve-Codina, Beatriz Martin-Mur, Alejandro Barrallo-Gimeno, Jordi Llorens · FENS Forum 2024
In response to chronic stress, mammalian vestibular hair cells (HC) may undergo extrusion from the sensory epithelium. Before HC loss begins, the early damage is characterized by synaptic uncoupling and dismantlement of the calyceal junction, the cell adhesion complex formed between type I HCs and calyx afferents. This early pathology associates with the early loss of vestibular function, and both the initial epithelial and functional alterations are reversible. This study was aimed at identifying key gene expression responses associated with these phenomena. We used three animal models of chr
ePoster · Neuroscience