Attentional set-shifting task: An approach to assess prefrontal activity patterns during behavioral flexibility in aged mice
Francisca García, Pablo Fuentealba, Wael El-Deredy, Ignacio Negrón-Oyarzo · FENS Forum 2024
Normal aging is characterized by a decline in several cognitive faculties, including the ability to adapt behavior in response to changing environmental contingencies.This ability, known as behavioral flexibility (BF) can be examined by the attentional set-shifting task (ASST), which has been used in rodent to evaluate cognitive impairment involving dysfunction in the prefrontal cortex (PFC), a core feature of several neuropsychiatric disorders. However, this test has not been used to assess BF in aged mice.We evaluated and compared BF between adult and aged mice with the ASST. Here, rodents l
ePoster · Neuroscience