Non-invasive sensory stimulation mitigates stress-induced neuroimmune responses in a sex- and frequency-specific manner
Tina Franklin, Matthew Goodson, Hector Zepeda, Sara Bitarafan, Nancy Kye, Alexia King, Jacob Kraus, Luke Braun, Ashley Prichard, Steven Sloan, Levi Wood, Annabelle Singer · FENS Forum 2024
Chronic stress promotes life-long risk for neuropsychiatric decline by increasing neuroinflammation and disrupting synaptic health and plasticity. Our lab and others have demonstrated that non-invasive gamma sensory stimulation (flicker) modulates immune signaling, restores microglial function, and improves cognitive performance in male mouse models of Alzheimer’s disease. However, no research to date has studied the effects of flicker in the context of stress. Accordingly, our goal for this study was to determine if flicker mitigates neuropsychiatric-like behavioral deficits and rescues glial
ePoster · Neuroscience