Representation of high and low frequency mouse vocalizations in the auditory midbrain and amygdala of Fragile X mice
Julia Freitag, Lea Marcks, Mareike Pfaffernoschke, Hannah Possner, Cornelia Wucke, Michal Wojcik, Daniel Breslav, Jérémie Sibille, Jens Kremkow, Thorsten Becker, Ursula Koch · FENS Forum 2024
Fragile X syndrome (FXS), is the most common monogenetic cause of mental impairment and autistic traits. Symptoms in people with FXS include auditory hypersensitivity and communication problem, which is recapitulated in the FXS mouse model. Previous studies in FXS mice showed only moderate increased neural activity levels in different parts of the ascending auditory pathways in response to simple tones. Here we characterized whether complex sounds with a behavioural relevance, such as vocalizations, evoke neural activity patterns that differ between FXS KO and WT mice. We used playback of low-
ePoster · Neuroscience