Longitudinal autophagy profiling of mammalian brain circuits reveals dynamic and sustained mitophagy throughout healthy aging
Anna Rappe, Homa Ehsan, Fumi Suomi, Helena A. Vihinen, Eija S. Jokitalo, Thomas G. McWilliams · FENS Forum 2024
Aims: Mitochondrial damage is neutralised by mitophagy, thereby preventing cellular dysfunction and apoptosis. Mitophagy is the selective autophagy of mitochondria and has long been linked to age-dependent neurodegenerative disorders, including Parkinson’s and Alzheimer’s disease. . In cell-based systems and short-lived model organisms, mitophagy declines with age. However, the trajectories of mitophagy within the aging mammalian brain remain unexplored. We profiled mitophagy and macroautophagy within intact brain tissues using advanced genetically-encoded optical reporter mice. Methods: We an
ePoster · Neuroscience