Unmasking microglial responses to traumatic brain injury and neural probes through morphometric analysis – MicroFACE
Vatsalkumar Daxeshkumar Jariwala, Carloa Haas, Ulrich Hofmann, Vidhya Ravi, Janne Töykkälä, Midori Johnston, Jürgen Beck, Kevin Joseph · FENS Forum 2024
The implantation of neural probes results in focal Traumatic Brain Injury (TBI), subsequently triggering a local neuroinflammatory response. Microglia, the brain's resident immune cells, exhibit distinctive transcriptional and morphological shifts upon activation, serving as a frontline defense against cerebral damage or infection. However, limited information exists regarding the spatial organization of these shifts during recovery. In this study, we tracked changes in the spatial organization of activated microglial phenotypes around the injury zone across a chronic period of 18 weeks after
ePoster · Neuroscience