P2X4 receptors contribute to lysosomal properties and functions
Sara Carracedo, Congiu Ludovica, Paloma Gilda Mata, Amélie Cordovado, Maria Domercq, Eric Boué-Grabot · FENS Forum 2024
P2X receptors are ligand-gated cation channels that play key roles in the central nervous system (CNS). Among those, P2X4 receptor, the most abundant P2X receptors expressed in the brain including neurons and microglia, are constitutively internalized and retained mainly into the lysosomes with a weak surface expression in normal conditions. Microglia functions have been directly linked to the regulation of lysosomal activity, which contributes to the brain homeostasis. Interestingly, P2X4 preserve their functionality into lysosomes and their activation by intraluminal ATP allows calcium influ
ePoster · Neuroscience